Endocrine Abstracts

Our research has embraced fish, reptilian and mammalian models, including Man. Investigations of endocrine control of sodium and water management and more recently calcium homeostasis, integrate molecular, biochemical, cellular and whole organism approaches. In recognition of the high level of conservation of these vital body processes through the vertebrate series, key research questions have been moved back and forth between species. This has brought experience and knowledge...

Much interest has recently focused on the effects in adulthood of an altered in utero environment. We have previously shown that the adult offspring of diabetic rats show reduced urinary calcium output and re-modelling of bone (Hamilton et al 1998, Proc. 3rd Europ. Kidney Res. Forum). Here we tested the hypothesis that changes in renal handling of calcium are the primary in utero effect of diabetes mellitus and are present immediately after birt...